1bfe: Difference between revisions

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[[Image:1bfe.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_1bfe", creates the "Structure Box" on the page.
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{{STRUCTURE_1bfe|  PDB=1bfe  |  SCENE=  }}  
{{STRUCTURE_1bfe|  PDB=1bfe  |  SCENE=  }}  
===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95===
===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95===
{{ABSTRACT_PUBMED_8674113}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_8674113}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8674113}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:008674113</ref><ref group="xtra">PMID:017096593</ref><references group="xtra"/>
<ref group="xtra">PMID:008674113</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Doyle, D A.]]
[[Category: Doyle, D A.]]

Revision as of 06:44, 10 April 2014

Template:STRUCTURE 1bfe

THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95

Template:ABSTRACT PUBMED 8674113

Function

[DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.[1] [2]

About this Structure

1bfe is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113
  1. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200
  2. ↑ Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101

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