1wmg: Difference between revisions

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~~[[Image:1wmg.png|left|200px]]~~

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===Crystal structure of the UNC5H2 death domain===

==Function==

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[[http://www.uniprot.org/uniprot/UNC5B_MOUSE UNC5B_MOUSE]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).<ref>PMID:15729359</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_17139086}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 17139086 is the PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_17139086}}~~

==About this Structure==

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==Reference==

[[Category: Mus musculus]]

[[Category: Handa, N.]]

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-[[Image:1wmg.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1wmg", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_1wmg|  PDB=1wmg  |  SCENE=  }}
 ===Crystal structure of the UNC5H2 death domain===
+{{ABSTRACT_PUBMED_17139086}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/UNC5B_MOUSE UNC5B_MOUSE]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).<ref>PMID:15729359</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_17139086}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 17139086 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_17139086}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:017139086</ref><references group="xtra"/>
+<ref group="xtra">PMID:017139086</ref><references group="xtra"/><references/>
 [[Category: Mus musculus]]
 [[Category: Handa, N.]]