1n4s: Difference between revisions

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[[Image:1n4s.png|left|200px]]
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{{STRUCTURE_1n4s|  PDB=1n4s  |  SCENE=  }}  
{{STRUCTURE_1n4s|  PDB=1n4s  |  SCENE=  }}  
===Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product===
===Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product===
{{ABSTRACT_PUBMED_14609943}}


 
==Function==
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[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/PGTB1_RAT PGTB1_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.  
The line below this paragraph, {{ABSTRACT_PUBMED_14609943}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14609943 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14609943}}


==About this Structure==
==About this Structure==
[[1n4s]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4S OCA].  
[[1n4s]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4S OCA].  
==See Also==
*[[Farnesyltransferase|Farnesyltransferase]]


==Reference==
==Reference==
<ref group="xtra">PMID:014609943</ref><references group="xtra"/>
<ref group="xtra">PMID:014609943</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Beese, L S.]]
[[Category: Beese, L S.]]