1nu4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
m Protected "1nu4" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1nu4.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_1nu4", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1nu4|  PDB=1nu4  |  SCENE=  }}  
{{STRUCTURE_1nu4|  PDB=1nu4  |  SCENE=  }}  
===U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix===
===U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix===
{{ABSTRACT_PUBMED_12876372}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_12876372}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12876372 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12876372}}


==About this Structure==
==About this Structure==
Line 22: Line 10:


==Reference==
==Reference==
<ref group="xtra">PMID:012876372</ref><references group="xtra"/>
<ref group="xtra">PMID:012876372</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]

Revision as of 10:59, 16 April 2014

Template:STRUCTURE 1nu4

U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix

Template:ABSTRACT PUBMED 12876372

Function

[SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

About this Structure

1nu4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Rupert PB, Xiao H, Ferre-D'Amare AR. U1A RNA-binding domain at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1521-4. Epub 2003, Jul 23. PMID:12876372
  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1nu4&oldid=1914897"