1j75: Difference between revisions

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~~[[Image:1j75.png|left|200px]]~~

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===Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA===

==Function==

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[[http://www.uniprot.org/uniprot/ZBP1_MOUSE ZBP1_MOUSE]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.<ref>PMID:17618271</ref> <ref>PMID:19590578</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_11524677}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 11524677 is the PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_11524677}}~~

==About this Structure==

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==Reference==

[[Category: Mus musculus]]

[[Category: Behlke, J.]]

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-[[Image:1j75.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1j75", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_1j75|  PDB=1j75  |  SCENE=  }}
 ===Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA===
+{{ABSTRACT_PUBMED_11524677}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/ZBP1_MOUSE ZBP1_MOUSE]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.<ref>PMID:17618271</ref> <ref>PMID:19590578</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_11524677}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11524677 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11524677}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:011524677</ref><references group="xtra"/>
+<ref group="xtra">PMID:011524677</ref><references group="xtra"/><references/>
 [[Category: Mus musculus]]
 [[Category: Behlke, J.]]