1w6s: Difference between revisions

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==Overview==

The crystal structure of methanol dehydrogenase (MDH) from, Methylobacterium extorquens has been refined without stereochemical, restraints at a resolution of 1.2 A. The high-resolution data have defined, the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor, ring as entirely planar. The detailed definition of the active-site, geometry has shown many features that are similar to the, quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and, Pseudomonas putida, both of which possess MDH-like and cytochrome c-like, domains. Conserved features between the two types of PQQ-containing enzyme, suggest a common pathway for electron transfer between MDH and its, physiological electron acceptor cytochrome cL. A pathway for proton, transfer from the active site to the bulk solvent is also suggested.

The crystal structure of methanol dehydrogenase (MDH) from Methylobacterium extorquens has been refined without stereochemical restraints at a resolution of 1.2 A. The high-resolution data have defined the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor ring as entirely planar. The detailed definition of the active-site geometry has shown many features that are similar to the quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and Pseudomonas putida, both of which possess MDH-like and cytochrome c-like domains. Conserved features between the two types of PQQ-containing enzyme suggest a common pathway for electron transfer between MDH and its physiological electron acceptor cytochrome cL. A pathway for proton transfer from the active site to the bulk solvent is also suggested.

==About this Structure==

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[[Category: Anthony, C.]]

[[Category: Coates, L.]]

[[Category: Cooper, J.B.]]

[[Category: Cooper, J B.]]

[[Category: Erskine, P.T.]]

[[Category: Erskine, P T.]]

[[Category: Gill, R.]]

[[Category: Mohammed, F.]]

[[Category: Williams, P.A.]]

[[Category: Williams, P A.]]

[[Category: Wood, S.P.]]

[[Category: Wood, S P.]]

[[Category: CA]]

[[Category: GOL]]

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[[Category: pqq]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of methanol dehydrogenase (MDH) from, Methylobacterium extorquens has been refined without stereochemical, restraints at a resolution of 1.2 A. The high-resolution data have defined, the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor, ring as entirely planar. The detailed definition of the active-site, geometry has shown many features that are similar to the, quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and, Pseudomonas putida, both of which possess MDH-like and cytochrome c-like, domains. Conserved features between the two types of PQQ-containing enzyme, suggest a common pathway for electron transfer between MDH and its, physiological electron acceptor cytochrome cL. A pathway for proton, transfer from the active site to the bulk solvent is also suggested.
+The crystal structure of methanol dehydrogenase (MDH) from Methylobacterium extorquens has been refined without stereochemical restraints at a resolution of 1.2 A. The high-resolution data have defined the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor ring as entirely planar. The detailed definition of the active-site geometry has shown many features that are similar to the quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and Pseudomonas putida, both of which possess MDH-like and cytochrome c-like domains. Conserved features between the two types of PQQ-containing enzyme suggest a common pathway for electron transfer between MDH and its physiological electron acceptor cytochrome cL. A pathway for proton transfer from the active site to the bulk solvent is also suggested.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Anthony, C.]]
 [[Category: Coates, L.]]
-[[Category: Cooper, J.B.]]
+[[Category: Cooper, J B.]]
-[[Category: Erskine, P.T.]]
+[[Category: Erskine, P T.]]
 [[Category: Gill, R.]]
 [[Category: Mohammed, F.]]
-[[Category: Williams, P.A.]]
+[[Category: Williams, P A.]]
-[[Category: Wood, S.P.]]
+[[Category: Wood, S P.]]
 [[Category: CA]]
 [[Category: GOL]]
@@ Line 32: / Line 32: @@
 [[Category: pqq]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:20:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:02 2008''