HEAT Repeat: Difference between revisions

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'''HEAT repeat motif'''

The protein domain HEAT is found in a number of diverse eukaryotic cytoplasmic proteins, including the four that ~~the~~ give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3) 1, protein phosphatase 2A (PP2A) 2, and the yeast PI3‐kinase TOR1). The HEAT domain consists of repeats of ~47 residues that form two anti‐parallel α‐helices and two turns arranged about a common axis. These repeats are linked by flexible inter‐unit loops. A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively. Thus, repeats form rod‐like helical structures, which are involved in intracellular transport.

The protein domain HEAT is found in a number of diverse eukaryotic cytoplasmic proteins, including the four that give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3) 1, protein phosphatase 2A (PP2A) 2, and the yeast PI3‐kinase TOR1). The HEAT domain consists of repeats of ~47 residues that form two anti‐parallel α‐helices and two turns arranged about a common axis. These repeats are linked by flexible inter‐unit loops. A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively. Thus, repeats form rod‐like helical structures, which are involved in intracellular transport.

The HEAT repeat family is related to armadillo/beta‐catenin‐like repeats. Similarities between HEAT and Armadillo (ARM) repeat families are found in the conserved residues that form the hydrophobic cores. In contrast to ARM repeats, HEAT repeats are more variable in length, amino acid sequence and 3D-structure.

HEAT Repeat: Difference between revisions

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-   '''HEAT repeat motif'''
+'''HEAT repeat motif'''
-The protein domain HEAT is found in a number of diverse eukaryotic cytoplasmic proteins, including the four that the give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3) 1, protein phosphatase 2A (PP2A) 2, and the yeast PI3‐kinase TOR1). The HEAT domain consists of repeats of ~47 residues that form two anti‐parallel α‐helices and two turns arranged about a common axis. These repeats are linked by flexible inter‐unit loops. A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively. Thus, repeats form rod‐like helical structures, which are involved in intracellular transport.
+The protein domain HEAT is found in a number of diverse eukaryotic cytoplasmic proteins, including the four that give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3) 1, protein phosphatase 2A (PP2A) 2, and the yeast PI3‐kinase TOR1). The HEAT domain consists of repeats of ~47 residues that form two anti‐parallel α‐helices and two turns arranged about a common axis. These repeats are linked by flexible inter‐unit loops. A signature motif of the HEAT repeats is the presence of conserved Asp and Arg residues at positions 19 and 25, respectively. Thus, repeats form rod‐like helical structures, which are involved in intracellular transport.
 The HEAT repeat family is related to armadillo/beta‐catenin‐like repeats. Similarities between HEAT and Armadillo (ARM) repeat families are found in the conserved residues that form the hydrophobic cores. In contrast to ARM repeats, HEAT repeats are more variable in length, amino acid sequence and 3D-structure.