2bkz: Difference between revisions
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==Overview== | ==Overview== | ||
The synthesis and the preliminary expansion of this new class of CDK2 | The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Transferred entry: 2 | [[Category: Transferred entry: 2 7.11 1]] | ||
[[Category: Bargiottia, A.]] | [[Category: Bargiottia, A.]] | ||
[[Category: Brasca, M | [[Category: Brasca, M G.]] | ||
[[Category: Cameron, A.]] | [[Category: Cameron, A.]] | ||
[[Category: Dalessio, R.]] | [[Category: Dalessio, R.]] | ||
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[[Category: Roletto, F.]] | [[Category: Roletto, F.]] | ||
[[Category: Tibolla, M.]] | [[Category: Tibolla, M.]] | ||
[[Category: Vazquez, M | [[Category: Vazquez, M L.]] | ||
[[Category: Vulpetti, A.]] | [[Category: Vulpetti, A.]] | ||
[[Category: SBC]] | [[Category: SBC]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:53 2008'' | ||
