Amyloid beta: Difference between revisions
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<StructureSection load=1iyt size='500' side='right' caption='amyloid-beta(1-42)', ([[1dm0]])' scene=''> | <StructureSection load=1iyt size='500' side='right' caption='amyloid-beta(1-42)', ([[1dm0]])' scene=''> | ||
==Introduction== | ==Introduction== | ||
'''Alzheimer's disease''' is characterized by extracellular proteic plaques and intracellular neurofibrillary tangles.<ref name="structure">PMID: 12423364</ref> These plaques are collections of fibrils consisting mostly of beta-amyloid <scene name='Amyloid_beta/Fibrils/1'>fibrils</scene>. These | '''Alzheimer's disease''' is characterized by extracellular proteic plaques and intracellular neurofibrillary tangles.<ref name="structure">PMID: 12423364</ref> These plaques are collections of fibrils consisting mostly of beta-amyloid <scene name='Amyloid_beta/Fibrils/1'>fibrils</scene>. These fibrils are aggregates of beta-sheets. The oxidative stress that an affected brain is under is further proof of the toxicity of amyloid beta. When amyloid beta is in contact with metal ions and oxygen reactive oxygen species (especially hydrogen peroxide) are created. <ref name="alz">PMID:18305836</ref> | ||
'''Amyloids''' are insoluble fibrous proteins | '''Amyloids''' are insoluble fibrous proteins | ||
