ToxT: Difference between revisions

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==Introduction==

ToxT is a molecule at the end of a transcriptional cascade that autoregulates the transcription of the primary virulence factors of Vibrio cholerae[http://http://en.wikipedia.org/wiki/Vibrio_cholerae] and of itself. These two factors, cholera toxin (CT)[http://http://en.wikipedia.org/wiki/Cholera_toxin] and the toxin co-regulated pilus (TCP), are instrumental in causing the disease cholera[http://http://en.wikipedia.org/wiki/Cholera]. This is an intestinal infection resulting in massive water loss in the affected individual, causing extreme dehydration.[http://http://en.wikipedia.org/wiki/Cholera]

ToxT is a molecule at the end of a transcriptional cascade that autoregulates the transcription of the primary virulence factors of Vibrio cholerae[http://http://en.wikipedia.org/wiki/Vibrio_cholerae] and itself. These two factors, cholera toxin (CT)[http://http://en.wikipedia.org/wiki/Cholera_toxin] and the toxin co-regulated pilus (TCP), are instrumental in causing the disease cholera[http://http://en.wikipedia.org/wiki/Cholera]. This is an intestinal infection resulting in massive water loss in the affected individual, causing extreme dehydration.[http://http://en.wikipedia.org/wiki/Cholera]

==Structural Features==

ToxT belongs to a family of transcriptional regulators known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is defined by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref>

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 ==Introduction==
-ToxT is a molecule at the end of a transcriptional cascade that autoregulates the transcription of the primary virulence factors of <i>Vibrio cholerae</i>[http://http://en.wikipedia.org/wiki/Vibrio_cholerae] and of itself. These two factors, cholera toxin (CT)[http://http://en.wikipedia.org/wiki/Cholera_toxin] and the toxin co-regulated pilus (TCP), are instrumental in causing the disease <b>cholera</b>[http://http://en.wikipedia.org/wiki/Cholera]. This is an intestinal infection resulting in massive water loss in the affected individual, causing extreme dehydration.[http://http://en.wikipedia.org/wiki/Cholera]
+<b>ToxT</b> is a molecule at the end of a transcriptional cascade that autoregulates the transcription of the primary virulence factors of <i>Vibrio cholerae</i>[http://http://en.wikipedia.org/wiki/Vibrio_cholerae] and itself. These two factors, cholera toxin (CT)[http://http://en.wikipedia.org/wiki/Cholera_toxin] and the toxin co-regulated pilus (TCP), are instrumental in causing the disease <b>cholera</b>[http://http://en.wikipedia.org/wiki/Cholera]. This is an intestinal infection resulting in massive water loss in the affected individual, causing extreme dehydration.[http://http://en.wikipedia.org/wiki/Cholera]
+==Structural Features==
+ToxT belongs to a family of transcriptional regulators known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is defined by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref>