Amyloid beta: Difference between revisions
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'''Pore Formation''' | '''Pore Formation''' | ||
Amyloid beta can adhere to endothelial cell walls and create lesions, eventually a large deposite will cause cerrbral hemorrhage. The pores cause loss of calcium homeostasis and an influx of Ca2+ into neurons.<ref name="alz" /> | Amyloid beta can adhere to endothelial cell walls and create lesions, eventually a large deposite will cause cerrbral hemorrhage. The pores cause loss of calcium homeostasis and an influx of Ca2+ into neurons.<ref name="alz" /> | ||
'''Interaction with tau''' | |||
Tau proteins function to stabilize microtubules [[http://en.wikipedia.org/wiki/Tau_protein]]. Association between Tau proteins and amyloid beta results in dissociation of tau from microtubules which collapses the axonal structure leading to the death of neurons.<ref name="alz" /> | |||
'''Binding ApoE''' | |||
