ToxT: Difference between revisions

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In this resolved structure, <scene name='ToxT_Transcriptional_Regulator_in_Vibrio_cholerae/Pam/2'>cis-palmitoleate</scene>[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3gbg&template=ligands.html&l=1.1] is present and bound in the beta sheet barrel (further discussed below). This unsaturated fatty acid reduces virulence expression in <i>Vibrio cholerae</i>.

==Structural Features==

==Other Structural Features==

ToxT belongs to a family of transcriptional regulators headed by and known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is characterized by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref> The two HTH regions are linked by a very polar alpha helix. The overall domain is composed of seven alpha helices.<ref name="structure">PMID: 20133655</ref>

ToxT belongs to a family of transcriptional regulators headed by and known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is characterized by a 100 amino acid region of sequence similarity that forms a <scene name='ToxT_Transcriptional_Regulator_in_Vibrio_cholerae/Two_hth_domains/1'>DNA-binding domain</scene> with two helix-turn-helix motifs (helix in blue, turn in teal). <ref name="arac">PMID: 11282467</ref> The two HTH regions are linked by a very polar alpha helix (shown in black). The overall domain is composed of seven alpha helices.<ref name="structure">PMID: 20133655</ref>

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@@ Line 12: / Line 12: @@
 In this resolved structure, <scene name='ToxT_Transcriptional_Regulator_in_Vibrio_cholerae/Pam/2'>cis-palmitoleate</scene>[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3gbg&template=ligands.html&l=1.1] is present and bound in the beta sheet barrel (further discussed below). This unsaturated fatty acid reduces virulence expression in <i>Vibrio cholerae</i>.
-==Structural Features==
+==Other Structural Features==
-ToxT belongs to a family of transcriptional regulators headed by and known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is characterized by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref> The two HTH regions are linked by a very polar alpha helix. The overall domain is composed of seven alpha helices.<ref name="structure">PMID: 20133655</ref>
+ToxT belongs to a family of transcriptional regulators headed by and known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is characterized by a 100 amino acid region of sequence similarity that forms a <scene name='ToxT_Transcriptional_Regulator_in_Vibrio_cholerae/Two_hth_domains/1'>DNA-binding domain</scene> with two helix-turn-helix motifs (helix in blue, turn in teal). <ref name="arac">PMID: 11282467</ref> The two HTH regions are linked by a very polar alpha helix (shown in black). The overall domain is composed of seven alpha helices.<ref name="structure">PMID: 20133655</ref>
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