ToxT: Difference between revisions
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==Further Study== | ==Further Study== | ||
Conclusive results about what activates ToxT itself has not yet been found. The varying activity of ToxT dependent on the presence of <i>cis</i>-palmitoleate or other unsaturated fatty acids represents a detailed method of effective pathogenicity in humans, but may not be a reasonable target for drug treatment. By restricting transcription (and thus translation and protein production) of virulence genes until the bacterium is determined to be in a favorable location for infection, <i>Vibrio cholerae</i> avoids wasting energy producing virulence factors that will just be cleared by the intestine. This is a specific mechanism to ensure that the bacterium also injects CT and TCP where they will do the most damage, | Conclusive results about what activates ToxT itself has not yet been found. The varying activity of ToxT dependent on the presence of <i>cis</i>-palmitoleate or other unsaturated fatty acids represents a detailed method of effective pathogenicity in humans, but may not be a reasonable target for drug treatment. By restricting transcription (and thus translation and protein production) of virulence genes until the bacterium is determined to be in a favorable location for infection, <i>Vibrio cholerae</i> avoids wasting energy producing virulence factors that will just be cleared by the intestine. This is a specific mechanism to ensure that the bacterium also injects CT and TCP where they will do the most damage, perpetuating the infection. <ref>Kenneth Todar [http://www.textbookofbacteriology.net/cholera.html] ''Vibrio cholerae'' and Asiatic Cholera, Todar's Online Textbook of Bacteriology. Date of access: 2011-11-28.</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
