2bre: Difference between revisions

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==Overview==

High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a, novel and potent (7.1 microM) inhibitor of Hsp90 ATPase activity. Here, we, describe the synthesis of CCT018159 and a number of close analogues, together with data on their biochemical properties. Some initial, structure-activity relationships are discussed, as well as the crystal, structure of CCT018159 bound to Hsp90.

High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a novel and potent (7.1 microM) inhibitor of Hsp90 ATPase activity. Here, we describe the synthesis of CCT018159 and a number of close analogues together with data on their biochemical properties. Some initial structure-activity relationships are discussed, as well as the crystal structure of CCT018159 bound to Hsp90.

==About this Structure==

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[[Category: Saccharomyces cerevisiae]]

[[Category: Single protein]]

[[Category: Pearl, L.H.]]

[[Category: Pearl, L H.]]

[[Category: Prodromou, C.]]

[[Category: Roe, S.M.]]

[[Category: Roe, S M.]]

[[Category: KJ2]]

[[Category: 3d-structure]]

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[[Category: multigene family]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:50 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a, novel and potent (7.1 microM) inhibitor of Hsp90 ATPase activity. Here, we, describe the synthesis of CCT018159 and a number of close analogues, together with data on their biochemical properties. Some initial, structure-activity relationships are discussed, as well as the crystal, structure of CCT018159 bound to Hsp90.
+High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a novel and potent (7.1 microM) inhibitor of Hsp90 ATPase activity. Here, we describe the synthesis of CCT018159 and a number of close analogues together with data on their biochemical properties. Some initial structure-activity relationships are discussed, as well as the crystal structure of CCT018159 bound to Hsp90.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
-[[Category: Pearl, L.H.]]
+[[Category: Pearl, L H.]]
 [[Category: Prodromou, C.]]
-[[Category: Roe, S.M.]]
+[[Category: Roe, S M.]]
 [[Category: KJ2]]
 [[Category: 3d-structure]]
@@ Line 24: / Line 24: @@
 [[Category: multigene family]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:27:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:50 2008''