2bt0: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structure of a previously reported screening hit 1 (CCT018159) | The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barril, X.]] | [[Category: Barril, X.]] | ||
[[Category: Brough, P | [[Category: Brough, P A.]] | ||
[[Category: Cansfield, J | [[Category: Cansfield, J E.]] | ||
[[Category: Drysdale, M | [[Category: Drysdale, M J.]] | ||
[[Category: Dymock, B | [[Category: Dymock, B W.]] | ||
[[Category: Hubbard, R | [[Category: Hubbard, R E.]] | ||
[[Category: Massey, A.]] | [[Category: Massey, A.]] | ||
[[Category: Mcdonald, E.]] | [[Category: Mcdonald, E.]] | ||
[[Category: Roughley, S | [[Category: Roughley, S D.]] | ||
[[Category: Surgenor, A.]] | [[Category: Surgenor, A.]] | ||
[[Category: Webb, P.]] | [[Category: Webb, P.]] | ||
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[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:41:19 2008'' | ||
