Sandbox Reserved 382: Difference between revisions
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== Function == | == Function == | ||
The primary function of Aromatase is to produce estrogens by aromatizing androgens. Aromatase converts androstenedione to estrogen and testosterone to estradiol. <ref> "Aromatase Products" [http://www.novusbio.com/aromatase#13225047480835&ga_enabled%3B0] </ref> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce this female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | The primary function of Aromatase is to produce estrogens by aromatizing androgens. Aromatase converts androstenedione to estrogen and testosterone to estradiol. <ref> "Aromatase Products" [http://www.novusbio.com/aromatase#13225047480835&ga_enabled%3B0] </ref> Aromatase is also a key enzyme in the biosynthesis of estrogens through a process called steroidogenesis. This enzyme helps produce this female sex hormone, estrogen, that helps to fuel the growth of hormone receptor-positive breast cancer. | ||
[[Image:Aromatase_Structure.jpg|260px|left|The ribbon diagram displaying the overall structure of human placental aromatase|]] | [[Image:Aromatase_Structure.jpg|260px|left|'The ribbon diagram displaying the overall structure of human placental aromatase'|]] | ||
== Structure== | == Structure== | ||
Due to the membrane-bound nature of mammalian cytochromes P450 (CYP), the structural characterization is extremely difficult. Aromatase is a monomeric enzyme composed of a heme-prosthetic group and a single polypeptide chain consisting of 503 amino-acid residues. <ref> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. "X-ray Structure of Human Aromatase Reveals An Androgen Specific Active Site". [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/] </ref> One important feature of CYPs is the iron-containing porphyrin group at the enzyme active site. <ref> PMID: 16395678 </ref> Aromatase is anchored to the endoplasmic reticulum by the amino terminal transmembrane domain. | Due to the membrane-bound nature of mammalian cytochromes P450 (CYP), the structural characterization is extremely difficult. Aromatase is a monomeric enzyme composed of a heme-prosthetic group and a single polypeptide chain consisting of 503 amino-acid residues. <ref> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. "X-ray Structure of Human Aromatase Reveals An Androgen Specific Active Site". [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/] </ref> One important feature of CYPs is the iron-containing porphyrin group at the enzyme active site. <ref> PMID: 16395678 </ref> Aromatase is anchored to the endoplasmic reticulum by the amino terminal transmembrane domain. | ||
