2byh: Difference between revisions

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==Overview==

Information from X-ray crystal structures of Hsp90 inhibitors bound to the, human Hsp90 molecular chaperone was used to assist in the design of, 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel, inhibitors of Hsp90. Accessing an extra interaction with the protein via, Phe138 gave a significant increase in binding potency compared to similar, analogues that do not make this interaction.

Information from X-ray crystal structures of Hsp90 inhibitors bound to the human Hsp90 molecular chaperone was used to assist in the design of 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel inhibitors of Hsp90. Accessing an extra interaction with the protein via Phe138 gave a significant increase in binding potency compared to similar analogues that do not make this interaction.

==About this Structure==

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[[Category: Barril, X.]]

[[Category: Beswick, M.]]

[[Category: Brough, P.A.]]

[[Category: Brough, P A.]]

[[Category: Drysdale, M.J.]]

[[Category: Drysdale, M J.]]

[[Category: Dymock, B.W.]]

[[Category: Dymock, B W.]]

[[Category: Grant, K.]]

[[Category: Massey, A.]]

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[[Category: pyrazole]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Feb ~~3 10~~:29:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:42:57 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Information from X-ray crystal structures of Hsp90 inhibitors bound to the, human Hsp90 molecular chaperone was used to assist in the design of, 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel, inhibitors of Hsp90. Accessing an extra interaction with the protein via, Phe138 gave a significant increase in binding potency compared to similar, analogues that do not make this interaction.
+Information from X-ray crystal structures of Hsp90 inhibitors bound to the human Hsp90 molecular chaperone was used to assist in the design of 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel inhibitors of Hsp90. Accessing an extra interaction with the protein via Phe138 gave a significant increase in binding potency compared to similar analogues that do not make this interaction.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Barril, X.]]
 [[Category: Beswick, M.]]
-[[Category: Brough, P.A.]]
+[[Category: Brough, P A.]]
-[[Category: Drysdale, M.J.]]
+[[Category: Drysdale, M J.]]
-[[Category: Dymock, B.W.]]
+[[Category: Dymock, B W.]]
 [[Category: Grant, K.]]
 [[Category: Massey, A.]]
@@ Line 32: / Line 32: @@
 [[Category: pyrazole]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:29:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:42:57 2008''