User:Iris To/Retinoblastoma Protein Regulation: Difference between revisions
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==Retinoblastoma Protein== | ==Retinoblastoma Protein== | ||
{{STRUCTURE_3n5u| PDB=3n5u | SCENE= }} | {{STRUCTURE_3n5u| PDB=3n5u | SCENE= }} | ||
The retinoblastoma protein (Rb) is a suppressor protein, also known as a tumor suppressor, involved in negative regulation of the cell cycle[http://en.wikipedia.org/wiki/Cell_cycle] due to its ability to bind the transcription factor E2F[http://en.wikipedia.org/wiki/E2F]. It acts as a cell cycle checkpoint during the G1 phase, determining if the cell cycle should continue or stop. In its normal state, Rb is activated, which prevents the cell cycle to continue because it can recruit transcriptional co-repressors, blocking transcription<ref name=Change >PMID: 12502741 </ref>. Rb is deactivated after being phosphorylated by Cyclin-dependent kinases (Cdks)[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase], and thus cannot associate factors that inhibit transcription factors that allow the cell cycle to continue. Unregulated deactivation of Rb can lead to uncontrolled growth of cells, which is why studying this protein is important in cancer research. [[Image: | The retinoblastoma protein (Rb) is a suppressor protein, also known as a tumor suppressor, involved in negative regulation of the cell cycle[http://en.wikipedia.org/wiki/Cell_cycle] due to its ability to bind the transcription factor E2F[http://en.wikipedia.org/wiki/E2F]. It acts as a cell cycle checkpoint during the G1 phase, determining if the cell cycle should continue or stop. In its normal state, Rb is activated, which prevents the cell cycle to continue because it can recruit transcriptional co-repressors, blocking transcription<ref name=Change >PMID: 12502741 </ref>. Rb is deactivated after being phosphorylated by Cyclin-dependent kinases (Cdks)[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase], and thus cannot associate factors that inhibit transcription factors that allow the cell cycle to continue. Unregulated deactivation of Rb can lead to uncontrolled growth of cells, which is why studying this protein is important in cancer research. [[Image:cellcycle.png]] | ||
==Regulation of Rb== | ==Regulation of Rb== | ||
