Sandbox Reserved 382: Difference between revisions
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<Structure load='3EQM' size='400' frame='true' align='right' caption='Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (PDB entry [http://www.pdb.org/pdb/explore/explore.do?structureId=3EQM])' scene='Insert optional scene name here' /> | <Structure load='3EQM' size='400' frame='true' align='right' caption='Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione (PDB entry [http://www.pdb.org/pdb/explore/explore.do?structureId=3EQM])' scene='Insert optional scene name here' /> | ||
== Introduction == | == Introduction == | ||
Aromatase belongs to the cytochrome p450 family. During aromatization reactions, Aromatase forms an electron-transfer complex with its partner, NADPH-cytochrome p450 reductase. This enzyme is localized in the endoplasmic reticulum of the cell and tissue specific promoters regulate its activity. In a number of species, including humans, aromatase can be found throughout the body in places such as the brain, gonads, blood vessels, endometrium, skin, bone and tissues including the placenta and adipose tissue. <ref> PMID: 11427156 </ref> There are many environmental factors that affect the activity of the aromatase enzyme and disrupt its function. Factors that increase the activity of the enzyme include age, obesity, gonadotropins, insulin, anti-m llerian hormone, alcohol and smoking. <ref name="products"> "Aromatase Products" [http://www.novusbio.com/aromatase#13225047480835&ga_enabled%3B0] </ref> | Aromatase belongs to the cytochrome p450 family. During aromatization reactions, Aromatase forms an electron-transfer complex with its partner, NADPH-cytochrome p450 reductase. This enzyme is localized in the endoplasmic reticulum of the cell and tissue specific promoters regulate its activity. <ref> PMID:21125383 </ref> In a number of species, including humans, aromatase can be found throughout the body in places such as the brain, gonads, blood vessels, endometrium, skin, bone and tissues including the placenta and adipose tissue. <ref> PMID: 11427156 </ref> There are many environmental factors that affect the activity of the aromatase enzyme and disrupt its function. Factors that increase the activity of the enzyme include age, obesity, gonadotropins, insulin, anti-m llerian hormone, alcohol and smoking. <ref name="products"> "Aromatase Products" [http://www.novusbio.com/aromatase#13225047480835&ga_enabled%3B0] </ref> | ||
== Function == | == Function == | ||
