Sandbox Reserved 381: Difference between revisions

The major mechanism for nutrient sensing in eukaryotes involves OGT.  OGT senses cellular glucose levels via <scene name='Sandbox_Reserved_381/Ternary_ogt_with_udp_ligand/1'>UDP</scene>-GlcNAc concentration, and responds by O-GlcNAcylating a broad range of nuclear anf cytoplasmic proteins.<ref>PMID:17460662</ref> Insulin-like signaling pathways and transcriptional activators that regulate glucose levels by controlling gluconeogenisis include proteins that are O-GlcNAcylated by OGT.<ref>PMID:18288188</ref>  Numerous O-GlcNAcylation sites are also phosphorylation sites, OGT is suggested to play a major role in modulating cellular kinase signaling cascades.<ref>PMID:12269319</ref> Widespread transcriptional regulations also involve OGT.<ref>PMID:19478141</ref>