Sandbox Reserved 383: Difference between revisions
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J. Biol. Chem. 284:21425-21434(2009) [PubMed: 19520868] [Abstract]</ref> | J. Biol. Chem. 284:21425-21434(2009) [PubMed: 19520868] [Abstract]</ref> | ||
==Structure== | ==Structure== | ||
Human dopamine D3 receptor is 64% helical and 1% beta sheet. The protein is composed of 20 helices and 3 beta sheet strands. The helices are made up of 312 residues and the bate sheets are made up of 9 residues. The entire protein consists of 481 residues.<ref>http://www.pdb.org/pdb/explore.do?structureId=3PBL</ref> | Human dopamine D3 receptor is 64% helical and 1% beta sheet. The protein is composed of 20 helices and 3 beta sheet strands. The helices are made up of 312 residues and the bate sheets are made up of 9 residues. The entire protein consists of 481 residues.<ref>http://www.pdb.org/pdb/explore.do?structureId=3PBL</ref> Dopamine D3 receptors are greatly expressed in the Islands of Calleja, a group of neural granule cells located within the ventral striatum in the brains of most animals, which is part of the limbic system. It is also found in the nucleus accumbens, a collection of neurons and forms the main part of the ventral striatum. | ||
==Ligands== | ==Ligands== | ||
Many non-selective prescription drugs bind to the D3 receptor. Some agonist, agents that stimulate, dopamine receptors include<ref>http://en.wikipedia.org/wiki/Category:Dopamine_agonists</ref>: | Many non-selective prescription drugs bind to the D3 receptor. Some agonist, agents that stimulate, dopamine receptors include<ref>http://en.wikipedia.org/wiki/Category:Dopamine_agonists</ref>: | ||
