Sandbox 208: Difference between revisions
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Rab-GDI does not facilitate Rab prenylation, but serves as a generic regulator for recycling of rab-GTPases for use in multiple rounds of membrane transport. It retrieves Rabs from the membrane and delivers it to the cytosol, controlling the distribution of Rabs between membranes and cytosol. GDI is believed to be stably associated only with GDP-loaded and prenylated Rabs proteins, ensuring retrieval of inactivated Rab GTPases from the membrane at the end of their functionnal cycle. Rab-GDI is critically important for the proper functionning of the vesicular transport machinery, and its deletion can be lethal. | Rab-GDI does not facilitate Rab prenylation, but serves as a generic regulator for recycling of rab-GTPases for use in multiple rounds of membrane transport. It retrieves Rabs from the membrane and delivers it to the cytosol, controlling the distribution of Rabs between membranes and cytosol. GDI is believed to be stably associated only with GDP-loaded and prenylated Rabs proteins, ensuring retrieval of inactivated Rab GTPases from the membrane at the end of their functionnal cycle. Rab-GDI is critically important for the proper functionning of the vesicular transport machinery, and its deletion can be lethal. | ||
== Structure == | |||
=== General structure === | |||
=== Substrate binding and catalytic mechanism === | |||
=== Regulation ??? === | |||
== Diseases == | |||
== Additional 3D Structures of Rab GDP-Dissociation Inhibitor == | |||
== Additional ressources == | |||
== References == | |||
