Sandbox Reserved 383: Difference between revisions
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==Ligands== | ==Ligands== | ||
Many non-selective prescription drugs bind to the D3 receptor. | Many non-selective prescription drugs bind to the D3 receptor. The binding of drugs either increases or inhibits the production of dopamine D3 receptors which helps to diminish complications that are caused by certain diseases. Some agonist, agents that stimulate, dopamine receptors include<ref>http://en.wikipedia.org/wiki/Category:Dopamine_agonists</ref>: | ||
*Amphetamine | *Amphetamine | ||
*Dopaminergic | *Dopaminergic | ||
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*Nafadotride | *Nafadotride | ||
Two ligands that are associated with dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide (<scene name='Sandbox_Reserved_383/Etq/1'>ETQ</scene>) and maltose (<scene name='Sandbox_Reserved_383/Mal/1'>MAL</scene>). ETQ binds to dopamine D3 receptor by Asp 110A and Phe346A. MAL binds by Asp 1020A, Glu 1022A, Glu1011A, and Leu1032A.<ref>http://www.pdb.org/pdb/explore.do?structureId=3PBL</ref> | Two ligands that are associated with dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide (<scene name='Sandbox_Reserved_383/Etq/1'>ETQ</scene>) and maltose (<scene name='Sandbox_Reserved_383/Mal/1'>MAL</scene>). ETQ binds to dopamine D3 receptor by Asp 110A and Phe346A. MAL binds by Asp 1020A, Glu 1022A, Glu1011A, and Leu1032A.<ref>http://www.pdb.org/pdb/explore.do?structureId=3PBL</ref> | ||
==Diseases== | ==Diseases== | ||
Variations in the DRD3 gene is connected with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder involving postural tremor of the arms, head, legs, body core, voice, jaw, and other facial muscles. This condition can be provoked by emotions, hunger, fatigue, and temperature extremes.<ref>"Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families." | Variations in the DRD3 gene is connected with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder involving postural tremor of the arms, head, legs, body core, voice, jaw, and other facial muscles. This condition can be provoked by emotions, hunger, fatigue, and temperature extremes.<ref>"Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families." | ||
