Sandbox 27: Difference between revisions

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TSH Receptor and M22 antibody ==


{{STRUCTURE_1st6 |  PDB=1st6 |  SCENE='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin autoinhibition }}
== Headline text ==


<scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains. Energetically, I997 is key to maintaining this autoinhibition.
 
The thyrotropin receptor (or TSH receptor or TSHR) is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein. It is on the surface of thyroid follicular cells. Once stimulated by TSH (Thyroid-Stimulating Hormone), THSR activates the production of thyroid hormones: thyroxine (T4) and triiodothyronine (T3).

Revision as of 11:45, 9 December 2011

PLEASE do NOT change this sandbox. It is currently reserved by Nathalie F, for use by Proteopedia Project, ESBS Strasbourg



== TSH Receptor and M22 antibody ==

Headline text

The thyrotropin receptor (or TSH receptor or TSHR) is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein. It is on the surface of thyroid follicular cells. Once stimulated by TSH (Thyroid-Stimulating Hormone), THSR activates the production of thyroid hormones: thyroxine (T4) and triiodothyronine (T3).

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