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[[Image:3tix.png|left|200px]]
==Crystal structure of the Chp1-Tas3 complex core==
<StructureSection load='3tix' size='340' side='right' caption='[[3tix]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast] and [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIX FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D9719.15, SMT3, SPBC83.03c, TAS3, YDR510W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast]), chp1, SPAC18G6.02c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tix RCSB], [http://www.ebi.ac.uk/pdbsum/3tix PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA interference (RNAi) is critical for the assembly of heterochromatin at Schizosaccharomyces pombe centromeres. Central to this process is the RNA-induced initiation of transcriptional gene silencing (RITS) complex, which physically anchors small noncoding RNAs to chromatin. RITS includes Ago1, the chromodomain protein Chp1, and Tas3, which forms a bridge between Chp1 and Ago1. Chp1 is a large protein with no recognizable domains, apart from its chromodomain. Here we describe how the structured C-terminal half of Chp1 binds the Tas3 N-terminal domain, revealing the tight association of Chp1 and Tas3. The structure also shows a PIN domain at the C-terminal tip of Chp1 that controls subtelomeric transcripts through a post-transcriptional mechanism. We suggest that the Chp1-Tas3 complex provides a solid and versatile platform to recruit both RNAi-dependent and RNAi-independent gene-silencing pathways for locus-specific regulation of heterochromatin.


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The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.,Schalch T, Job G, Shanker S, Partridge JF, Joshua-Tor L Nat Struct Mol Biol. 2011 Nov 13;18(12):1351-7. doi: 10.1038/nsmb.2151. PMID:22081013<ref>PMID:22081013</ref>
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{{STRUCTURE_3tix|  PDB=3tix  |  SCENE=  }}


===Crystal structure of the Chp1-Tas3 complex core===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_22081013}}, adds the Publication Abstract to the page
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[[Category: Fission yeast]]
{{ABSTRACT_PUBMED_22081013}}
 
==About this Structure==
[[3tix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae,_schizosaccharomyces_pombe Saccharomyces cerevisiae, schizosaccharomyces pombe] and [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIX OCA].
 
==Reference==
<ref group="xtra">PMID:022081013</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae, schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Joshua-Tor, L.]]
[[Category: Joshua-Tor, L.]]

Revision as of 06:25, 5 June 2014

Crystal structure of the Chp1-Tas3 complex core

3tix, resolution 2.90Å

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