3q3g: Difference between revisions

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[[Image:3q3g.png|left|200px]]
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{{STRUCTURE_3q3g|  PDB=3q3g  |  SCENE=  }}  
{{STRUCTURE_3q3g|  PDB=3q3g  |  SCENE=  }}  
===Crystal Structure of A-domain in complex with antibody===
===Crystal Structure of A-domain in complex with antibody===
{{ABSTRACT_PUBMED_22095715}}


==Disease==
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_22095715}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
(as it appears on PubMed at http://www.pubmed.gov), where 22095715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22095715}}


==About this Structure==
==About this Structure==
[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA].  
[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA].  
==See Also==
*[[Antibody|Antibody]]


==Reference==
==Reference==
<ref group="xtra">PMID:022095715</ref><references group="xtra"/>
<ref group="xtra">PMID:022095715</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
Retrieved from "https://proteopedia.org/3q3g"