2c6i: Difference between revisions
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==Overview== | ==Overview== | ||
Crystallographic and modelling data, in conjunction with a medicinal | Crystallographic and modelling data, in conjunction with a medicinal chemistry template-hopping approach, led to the identification of a series of novel and potent inhibitors of human cyclin-dependent kinase 2 (CDK2), with selectivity over glycogen synthase kinase-3beta (GSK-3beta). One example had a CDK2 IC(50) of 120 nM and showed selectivity over GSK-3beta of 167-fold. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferred entry: 2 | [[Category: Transferred entry: 2 7.11 1]] | ||
[[Category: Dokurno, P.]] | [[Category: Dokurno, P.]] | ||
[[Category: Murray, J | [[Category: Murray, J B.]] | ||
[[Category: Richardson, C | [[Category: Richardson, C M.]] | ||
[[Category: Surgenor, A | [[Category: Surgenor, A E.]] | ||
[[Category: DT1]] | [[Category: DT1]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
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[[Category: triazolopyrimidine inhibitor]] | [[Category: triazolopyrimidine inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:36 2008'' | ||
