Potassium Channel: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 20: | Line 20: | ||
This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University. | This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University. | ||
== | == 3D structures of Potassium Channels== | ||
''Update | ''Update June 2012'' | ||
Potassium channels (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | '''Potassium channels''' (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | ||
[[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br /> | [[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br /> | ||
| Line 81: | Line 81: | ||
[[2hg5]], [[2h8p]], [[2hfe]] - KCh + mFAB<br /> | [[2hg5]], [[2h8p]], [[2hfe]] - KCh + mFAB<br /> | ||
[[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br /> | [[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br /> | ||
[[3f5w]], [[1zwi]], [2hjf]] - mKCh (mutant) + antibody heavy+light chains<br /> | [[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br /> | ||
[[1k4c]], [[1k4d]] - SlKCh (mutant) + antibody heavy+light chains<br /> | [[1k4c]], [[1k4d]] - SlKCh (mutant) + antibody heavy+light chains<br /> | ||
[[2a0l]] - AeKCh + FV<br /> | [[2a0l]] - AeKCh + FV<br /> | ||
| Line 104: | Line 104: | ||
[[3spg]], [[3sph]] – cIRK 2.2 (mutant) + PIP2<br /> | [[3spg]], [[3sph]] – cIRK 2.2 (mutant) + PIP2<br /> | ||
[[3spi]] – cIRK 2.2 + PIP2<br /> | [[3spi]] – cIRK 2.2 + PIP2<br /> | ||
[[3spj]] – cIRK 2.2 (mutant) | [[3spj]] – cIRK 2.2 (mutant)<br /> | ||
[[3umk]] – hIRK TWIK-1<br /> | |||
[[3um7]] – hIRK TRAAK | |||
===MthK=== | ===MthK=== | ||
[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain - ''Methanobacterium thermoautrophicum''<br /> | |||
[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain<br /> | |||
[[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | [[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | ||
[[2aef]], [[3kxd]] - MthK RCK domain + Ca<br /> | [[2aef]], [[3kxd]] - MthK RCK domain + Ca<br /> | ||
[[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca | [[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca<br /> | ||
[[3r65]] – MthK pore domain (mutant) | |||
=== | ===Large conductance calcium-activated KCh=== | ||
[[3mt5]] - hBK cytoplasmic domain<br /> | [[3mt5]] - hBK cytoplasmic domain<br /> | ||
[[1jo6]] - BK beta 2 N-terminal KCNMB2 encoded LKCa - NMR | [[1jo6]] - BK beta 2 N-terminal KCNMB2 encoded LKCa - NMR<br /> | ||
[[3u6n]] – BK – ''Danio rerio'' | |||
===Potassium/Sodium channel=== | ===Potassium/Sodium channel=== | ||
| Line 127: | Line 130: | ||
[[3naf]] – hKCh α1 subunit | [[3naf]] – hKCh α1 subunit | ||
===Small conductance calcium-activated KCh=== | |||
[[1kkd]] – rKCh calmodulin-binding domain - NMR<br /> | |||
[[2pnv]] – rKCh leucine zipper domain SKCa – rat | |||
