3u8l: Difference between revisions

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[[Image:3u8l.jpg|left|200px]]
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{{STRUCTURE_3u8l|  PDB=3u8l  |  SCENE=  }}  
{{STRUCTURE_3u8l|  PDB=3u8l  |  SCENE=  }}  
===Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3570 (1-(5-phenylpyridin-3-yl)-1,4-diazepane)===
===Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3570 (1-(5-phenylpyridin-3-yl)-1,4-diazepane)===
{{ABSTRACT_PUBMED_22170047}}


==Function==
[[http://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.


==About this Structure==
==About this Structure==
[[3u8l]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8L OCA].  
[[3u8l]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8L OCA].  
==Reference==
<ref group="xtra">PMID:022170047</ref><references group="xtra"/><references/>
[[Category: Lymnaea stagnalis]]
[[Category: Lymnaea stagnalis]]
[[Category: Ahring, P K.]]
[[Category: Ahring, P K.]]

Revision as of 02:33, 20 September 2013

Template:STRUCTURE 3u8l

Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3570 (1-(5-phenylpyridin-3-yl)-1,4-diazepane)

Template:ABSTRACT PUBMED 22170047

Function

[ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.

About this Structure

3u8l is a 10 chain structure with sequence from Lymnaea stagnalis. Full crystallographic information is available from OCA.

Reference

  1. Rohde LA, Ahring PK, Jensen ML, Nielsen EO, Peters D, Helgstrand C, Krintel C, Harpsoe K, Gajhede M, Kastrup JS, Balle T. Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: unique role of halogen bonding revealed. J Biol Chem. 2012 Feb 3;287(6):4248-59. Epub 2011 Dec 13. PMID:22170047 doi:10.1074/jbc.M111.292243

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