Sandbox 27: Difference between revisions
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[[Image:JCI0526031.f1.jpg | thumb | right | Different domains of TSHR ]] | [[Image:JCI0526031.f1.jpg | thumb | right | Different domains of TSHR ]] | ||
This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains | This receptor is evolutionary classified as rhodopsin-like receptors of family A. It is consisted of five different domains (as represented on the opposite scheme) | ||
* '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain forms a concave surface (also with some contribution from the CD), it is responsible for the high affinity and selective binding of the corresponding hormones. | * '''An extracellular domain or ectodomain''': it consists of ten leucine-rich repeats, so also called '''leucine rich domain or LRD, or LRRs'''. This ectodomain forms a concave surface (also with some contribution from the CD), it is responsible for the high affinity and selective binding of the corresponding hormones. | ||
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* '''A C-terminal intracellular domain'''. | * '''A C-terminal intracellular domain'''. | ||
Full information about the LRD domain from [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] | Full information about the LRD domain from : [http://www.hotthyroidology.com/editorial_175.html Hot Thyroidology Journal] | ||
One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when THS is binding to LRD, the ectodomain would have a change of conformation which activates the transduction of the signal. | One of models for the receptor’s activation explains that interactions between ectodomain and extracellular loops would inhibit the activity of serpentine domain in the absence of stimulation. But when THS is binding to LRD, the ectodomain would have a change of conformation which activates the transduction of the signal. | ||
