Sandbox 27: Difference between revisions
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TSH is a hormone also known as "thyrotropin". It is a member of the Glycoprotein Hormone Family or GHF(like LH, FSH or hCG). TSH regulates the growth and the function of thyroid follicular cells by stimulating the secretion of thyroid hormones T3 and T4. These hormones play an important role in human reproduction, metabolism and cellular development. Therefore, this class of receptors is central to medical, pharmaceutical, and biological research. | TSH is a hormone also known as "thyrotropin". It is a member of the Glycoprotein Hormone Family or GHF(like LH, FSH or hCG). TSH regulates the growth and the function of thyroid follicular cells by stimulating the secretion of thyroid hormones T3 and T4. These hormones play an important role in human reproduction, metabolism and cellular development. Therefore, this class of receptors is central to medical, pharmaceutical, and biological research. | ||
The studies on the structure of | The studies on the structure of TSH receptor are based upon its binding to an antibody called M22. | ||
Crystals suitable for X-Ray diffraction analysis were solved at 2.55 A resolution. Zinc ions are used as cristallisation additive(there is no specific interaction with the protein). Further crystallographic information is available from [http://www.ncbi.nlm.nih.gov/pubmed/17542669 Pubmed] and ...... | |||
M22 is a thyroid stimulating human monoclonal antibody prepared using lymphocytes from a patient with Graves’ disease. It is an antibody to the TSHR. It mimics closely the binding of TSH on its receptor, so it stimulates the receptor and inhibits the binding of TSH to give rise to full activation of receptor mediated signal transduction. | M22 is a thyroid stimulating human monoclonal antibody prepared using lymphocytes from a patient with Graves’ disease. It is an antibody to the TSHR. It mimics closely the binding of TSH on its receptor, so it stimulates the receptor and inhibits the binding of TSH to give rise to full activation of receptor mediated signal transduction. | ||
le zinc est un additif de cristallisation et ne fait pas d'interaction spécifique avec la protéine. Il agit comme un cation divalent. Les adduits N-acetyl glucosamines sont des modifications post-traductionnelles classiques des protéines eucaryotiques et forment donc une liaison covalente avec les résidus aminés. | |||
== Signalling pathway == | == Signalling pathway == | ||
