Sandbox 27: Difference between revisions
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== Signalling pathway == | == Signalling pathway == | ||
[[Image:1.jpg | thumb | right]] | |||
[[Image:http://www.hotthyroidology.com/editorial_pics/editorial15_figure1.jpg]] | |||
TSH hormone or in our case the autoantibody M22 binds to its receptor (more precisely to the LRD). This binding actives the receptor and then small G-proteins coupled to the receptor. The alpha subunit stimulates enzymes of the cellular membrane. A cascade of reactions and second messengers pathways are involved and result in the stimulation and the synthesis of thyroid hormones T3 and T4. | TSH hormone or in our case the autoantibody M22 binds to its receptor (more precisely to the LRD). This binding actives the receptor and then small G-proteins coupled to the receptor. The alpha subunit stimulates enzymes of the cellular membrane. A cascade of reactions and second messengers pathways are involved and result in the stimulation and the synthesis of thyroid hormones T3 and T4. | ||
== Structure of the TSH Receptor == | == Structure of the TSH Receptor == | ||
