Sandbox 210: Difference between revisions
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[[Image:1h4l.jpg|left|200px]] | [[Image:1h4l.jpg|left|200px]] | ||
{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }} | {{STRUCTURE_1h4l| PDB=1h4l | SCENE= }} | ||
CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.<ref>doi:10.1007/s00894-009-0629-4</ref> | |||
Cyclin dependent kinase 5 (CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility. | |||
CDK5 could form a complex with p25, an other protein. | |||
==Structure== | ==Structure== | ||
===Sequence similarities=== | ===Sequence similarities=== | ||
The chains A and B of the | The chains A and B of the CDK5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator (p35). | ||
==Applications of | ==Applications of CDK5-p25 complex== | ||
==Biology== | ==Biology== | ||
=== | === CDK5-p25 complex Control === | ||
==References== | ==References== | ||
<references /> | <references /> | ||
