Sandbox 212: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Ndeye Coumba (talk | contribs) No edit summary |
Ndeye Coumba (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
Carnitine acyltransferases are a large family of enzymes that play a main role in cellular energy metabolism, i.e. fatty acid oxidation. These enzymes catalyze the | Carnitine acyltransferases are a large family of enzymes that play a main role in cellular energy metabolism, i.e. fatty acid oxidation. These enzymes catalyze the | ||
reversible exchange of acyl groups between Coenzyme A and carnitine. | reversible exchange of acyl groups between Coenzyme A and carnitine. | ||
Carnitine acyltransferases include three different classes of enzymes which are known as carnitine acetyltransferases (CrATs), carnitine octanoyltransferases (CrOTs) and carnitine palmityltransferase (CPTs). The three classes of differ in their acyl group specificity as well as their localization. | Carnitine acyltransferases include three different classes of enzymes which are known as carnitine acetyltransferases (CrATs), carnitine octanoyltransferases (CrOTs) and carnitine palmityltransferase (CPTs). The three classes of differ in their acyl group specificity as well as their localization. | ||
Being major enzymes in fatty acid oxidation carnitine acyltransferases are viewed as promising targets which can be used to develop successful therapeutics against type 2 diabetes, obesity and other human diseases. | Being major enzymes in fatty acid oxidation carnitine acyltransferases are viewed as promising targets which can be used to develop successful therapeutics against type 2 diabetes, obesity and other human diseases. | ||
