Sandbox 215: Difference between revisions
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==Structure== | ==Structure== | ||
=== | ===General overview of the structure=== | ||
CETP is a 476 amino acid residues protein which has an elongated “boomerang shape” with dimensions of 135Å X 30Å X 35Å. She has a molecular mass of 74 kDa and 28% of this mass is attributed to N-glycosylation at specific residues: 88, 240, 341 and 396. | CETP is a 476 amino acid residues protein which has an elongated “boomerang shape” with dimensions of 135Å X 30Å X 35Å. She has a molecular mass of 74 kDa and 28% of this mass is attributed to N-glycosylation at specific residues: 88, 240, 341 and 396. | ||
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* At each end of the protein there is a barrel which is constitued of highly twisted B-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A' | * At each end of the protein there is a barrel which is constitued of highly twisted B-sheet and two helices called A and B at the N-terminal and A', B' at C-terminal extremity. Helices B and B' are longer than A and A' | ||
* Between the two barrels there is a central B-sheet which is constitued of six antiparallel strands | * Between the two barrels there is a central B-sheet which is constitued of six antiparallel strands | ||
* At the C-terminal extremity there is a distorted amphiphathic helix called helix X which is an extension of C-teminal | * At the C-terminal extremity there is a distorted amphiphathic helix called helix X which is an extension of C-teminal interacting with N-terminal residues. | ||
===Four lipid binding sites=== | ===Four lipid binding sites=== | ||
