2j0a: Difference between revisions
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==Overview== | ==Overview== | ||
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify | Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]] | [[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chen, Y | [[Category: Chen, Y W.]] | ||
[[Category: Clausen, H.]] | [[Category: Clausen, H.]] | ||
[[Category: Cohen, S | [[Category: Cohen, S M.]] | ||
[[Category: Conti, E.]] | [[Category: Conti, E.]] | ||
[[Category: Jinek, M.]] | [[Category: Jinek, M.]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:56 2008'' | ||
