Sandbox 213: Difference between revisions
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= Structure = | = Structure = | ||
<StructureSection load='3cln' size='400' side='left' caption='Structure of calmodulin (PDB entry [[3cln]])' scene=''> | <StructureSection load='3cln' size='400' side='left' caption='Structure of calmodulin (PDB entry [[3cln]])' scene=''> | ||
'''Calmodulin''' [http://www.rcsb.org/pdb/101/motm_disscussed_entry.do?id=3cln] | '''Calmodulin''' [http://www.rcsb.org/pdb/101/motm_disscussed_entry.do?id=3cln] | ||
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Up to four calcium ions are bound by calmodulin via its four EF hand motifs. EF hands supply an electronegative environment for ion coordination. After calcium binding, hydrophobic methyl groups from methionine residues become exposed on the protein via conformational change. | Up to four calcium ions are bound by calmodulin via its four EF hand motifs. EF hands supply an electronegative environment for ion coordination. After calcium binding, hydrophobic methyl groups from methionine residues become exposed on the protein via conformational change. | ||
This presents hydrophobic surfaces, which can in turn bind to Basic Amphiphilic Helices (BAA helices) on the target protein. These helices contain complementary hydrophobic regions. The flexibility of Calmodulin's hinged region allows the molecule to "wrap around" its target. This property allows it to tightly bind to a wide range of different target proteins.</StructureSection> | This presents hydrophobic surfaces, which can in turn bind to Basic Amphiphilic Helices (BAA helices) on the target protein. These helices contain complementary hydrophobic regions. The flexibility of Calmodulin's hinged region allows the molecule to "wrap around" its target. This property allows it to tightly bind to a wide range of different target proteins.</StructureSection> | ||
*'''Three-dimensional structure of apocalmodulin''' | *'''Three-dimensional structure of apocalmodulin''' | ||
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Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels. | Apocalmodulin (ApoCaM) binds to other proteins and has other specific effects. It is essential role for life. The ApoCaM-binding proteins are a diverse group of at least 15 proteins including enzymes, actin-binding proteins, as well as cytoskeletal and other membrane proteins, including receptors and ion channels. | ||
<ref name="Najl V Valeyev1, Declan G Bates1, Pat Heslop-Harrison1,2, Ian Postlethwaite1 and Nikolay V Kotov. Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.BMC Systems Biology 2008, 2:48 doi:[[10.1186/1752-0509-2-48]]"/>. | <ref name="Najl V Valeyev1, Declan G Bates1, Pat Heslop-Harrison1,2, Ian Postlethwaite1 and Nikolay V Kotov. Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.BMC Systems Biology 2008, 2:48 doi:[[10.1186/1752-0509-2-48]]"/>. | ||
*'''Ca<sup>2+</sup>-bound calmodulin''' | *'''Ca<sup>2+</sup>-bound calmodulin''' | ||
