Sandbox207: Difference between revisions
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==Structure== | ==Structure [http://biology.kenyon.edu/BMB/Chime2/2005/Jenny/FRAMES/]== | ||
===Gene structure, family=== | ===Gene structure, family=== | ||
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:Moreover, the structure of CRP is different in diseased patients. Indeed, in some pathological conditions, the Human CRP is glycosylated. Analysis of the structure showed the systematic absence of two peptide fragments, one at the N-terminus (loop 1-6) in all patients, the other near the C-terminus (loop 189-191) in patients with osteogenic sarcoma and Cushing's syndrome. In an undiseased individual, glycosylation sites are inacessible due to the presence of the N-terminal. The loss of these two fragments exposed two potential glycosylation sites on a cleft door. The functional areas of the pentraxin structure remains the same since the Ca2+ and phosphocholine sites are on the opposite site of the pentraxin molecule. | :Moreover, the structure of CRP is different in diseased patients. Indeed, in some pathological conditions, the Human CRP is glycosylated. Analysis of the structure showed the systematic absence of two peptide fragments, one at the N-terminus (loop 1-6) in all patients, the other near the C-terminus (loop 189-191) in patients with osteogenic sarcoma and Cushing's syndrome. In an undiseased individual, glycosylation sites are inacessible due to the presence of the N-terminal. The loss of these two fragments exposed two potential glycosylation sites on a cleft door. The functional areas of the pentraxin structure remains the same since the Ca2+ and phosphocholine sites are on the opposite site of the pentraxin molecule. | ||
==Biomarker== | ==Biomarker== | ||
