Sandbox 213: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 79: | Line 79: | ||
When the Ca<sup>2+</sup> concentration falls, calcium dissociates and calmodulin is quickly released, inactivating the target. However, at least one important target protein is an exception to this rule. This is CaM-kinase II which can retain its active state after it has been activated by calmodulin. | When the Ca<sup>2+</sup> concentration falls, calcium dissociates and calmodulin is quickly released, inactivating the target. However, at least one important target protein is an exception to this rule. This is CaM-kinase II which can retain its active state after it has been activated by calmodulin. | ||
=CaMII kinase= | =CaMII kinase= | ||
Calmodulin plays an important role through kinase enzymes such as calcium/calmodulin-dependent kinase II (CaMKII) that is a multifunctional serine/threonine kinase found in many tissues. Activation of CaMKII contributes to synaptic plasticity and regulation of excitory synaptic transmission. The regulatory domain of CaMKII contains an autophosphorylation site, which is essential for its calcium-dependent activation. | Calmodulin plays an important role through kinase enzymes such as calcium/calmodulin-dependent kinase II (CaMKII) that is a multifunctional serine/threonine kinase found in many tissues. Activation of CaMKII contributes to synaptic plasticity and regulation of excitory synaptic transmission. The regulatory domain of CaMKII contains an autophosphorylation site, which is essential for its calcium-dependent activation. | ||
CaM kinases have a catalytic N-terminal domain, a regulator domain | CaM kinases have a catalytic N-terminal domain, a regulator domain and an association domain. The enzymes give an holoenzyme of dodecameric structure, the catalytics domains are found one's way out side, that permit of phosphorylate the residues between the sub-unit. Without Ca2+/calmodulin, the catalytic domain is self-inhibited by the regulator domain, which contains one sequence of type pseudo-substrate. Many CaM kinases give an homo-oligomeres or hetero-oligomeres. When there is an activation by the Ca2+/calmodulin complex, the CaM kinases actif are autophosphorylated one by one at the level of the threonine residues 286. | ||
=Family members= | =Family members= | ||
