Sandbox207: Difference between revisions

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In the presence of calcium, CRP is specifically bound in phosphocholine residues. We find phosphocholine in the microbial polysaccharides.

In the presence of calcium, CRP is '''specifically''' bound to phosphocholine residues. We find phosphocholine in the microbial polysaccharides.

The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but is exposed by cellular damages caused by phospholipases.

The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but '''is exposed by cellular damages caused by phospholipases'''.

After this connection, CRP activates the classical complement pathway in the absence of antibody, and opsonizes ligands, with the aim of their phagocytosis.

After this connection, CRP activates the '''classical complement pathway''' in the absence of antibody, and '''opsonizes ligands''', with the aim of their phagocytosis.

Indeed, when CRP is bound in the ligand, it is recognized by the factor CIq, what activates powerfully the classical complement pathway, committing the factor C3. There is then formation of the membrane attack complex C5-C9 on the surface of the ligand, what entails its phagocytosis.

[http://www.ncbi.nlm.nih.gov/pubmed/11532280 <6>]

Sandbox207: Difference between revisions

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@@ Line 60: / Line 60: @@
 <Structure load='1b09' size='250' frame='true' align='right' caption='CRP complexed with Phosphocholine' scene='Insert optional scene name here' />
-In the presence of calcium, CRP is specifically bound in phosphocholine residues. We find phosphocholine in the microbial polysaccharides.
+In the presence of calcium, CRP is '''specifically''' bound to phosphocholine residues. We find phosphocholine in the microbial polysaccharides.
-The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but is exposed by cellular damages caused by phospholipases.
+The wide distribution of phosphocholine in polysaccharides of pathogenic and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as the damaged membranes and necrosed cells of the host. The ligand, the phosphocholine, does not appear normally on the surface of cells, but '''is exposed by cellular damages caused by phospholipases'''.
-After this connection, CRP activates the classical complement pathway in the absence of antibody, and opsonizes ligands, with the aim of their phagocytosis.
+After this connection, CRP activates the '''classical complement pathway''' in the absence of antibody, and '''opsonizes ligands''', with the aim of their phagocytosis.
 Indeed, when CRP is bound in the ligand, it is recognized by the factor CIq, what activates powerfully the classical complement pathway, committing the factor C3. There is then formation of the membrane attack complex C5-C9 on the surface of the ligand, what entails its phagocytosis.
 [http://www.ncbi.nlm.nih.gov/pubmed/11532280 <6>]