Anthrax Lethal Factor: Difference between revisions
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{{STRUCTURE_1j7n| PDB=1j7n | SIZE=500| SCENE= |right|CAPTION=Anthrax toxin lethal factor complex with sulfate and Zn+2 ions [[1j7n]] }} | {{STRUCTURE_1j7n| PDB=1j7n | SIZE=500| SCENE= |right|CAPTION=Anthrax toxin lethal factor complex with sulfate and Zn+2 ions [[1j7n]] }} | ||
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The most will known case of biological warfare in recent times occurred in 2001, known as [http://en.wikipedia.org/wiki/2001_anthrax_attacks Amerithrax]. Anthrax spores are a top choice for biological warfare because their potency. Production of these spores are among the easiest of bioterror agents. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> They can be manipulated and produced in large quantities using basic microbiology techniques. Naturally occurring spores tend to aggregate making them less infection; they can easily be refined and dispersed. Because the anthrax spores are very robust; being able to survive for decades and are difficult to destroy, makes them excellent bioweapons. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> <ref>Kenneth Todar, PhD. (2008). http://textbookofbacteriology.net/Anthrax_3.html</ref> | The most will known case of biological warfare in recent times occurred in 2001, known as [http://en.wikipedia.org/wiki/2001_anthrax_attacks Amerithrax]. Anthrax spores are a top choice for biological warfare because their potency. Production of these spores are among the easiest of bioterror agents. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> They can be manipulated and produced in large quantities using basic microbiology techniques. Naturally occurring spores tend to aggregate making them less infection; they can easily be refined and dispersed. Because the anthrax spores are very robust; being able to survive for decades and are difficult to destroy, makes them excellent bioweapons. <ref>Brenda A. Wilson, Abigail A. Salyers, Dixie D. Whitt, and Malcolm E. Winkler. Third Edition. Bacterial Pathogenesis A Molecular Approach</ref> <ref>Kenneth Todar, PhD. (2008). http://textbookofbacteriology.net/Anthrax_3.html</ref> | ||
== 3D structures of anthrax lethal factor== | |||
[[1j7n]] – BaALF – Bacillus anthracis <br /> | |||
[[1pwp]], [[1pwq]], [[1pwu]], [[1zxv]] – BaALF + inhibitor <br /> | |||
[[1yqy]] – BaALF domains II-IV + inhibitor <br /> | |||
[[1pww]], [[1pwv]] – BaALF + peptide substrate <br /> | |||
[[3kwv]] – BaALF protective antigen-binding domain + protective antigen <br /> | |||
[[1yqy]] – BaALF domain IV - NMR<br /> | |||
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</StructureSection> | </StructureSection> | ||
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