3u5p: Difference between revisions

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[[Image:3u5p.jpg|left|200px]]
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{{STRUCTURE_3u5p|  PDB=3u5p  |  SCENE=  }}  
{{STRUCTURE_3u5p|  PDB=3u5p  |  SCENE=  }}  
===Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac histone peptide===
===Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac histone peptide===
{{ABSTRACT_PUBMED_22196728}}


==Disease==
[[http://www.uniprot.org/uniprot/TRI33_HUMAN TRI33_HUMAN]] Papillary or follicular thyroid carcinoma. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM33 is found in thyroid papillary carcinomas. Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_22196728}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/TRI33_HUMAN TRI33_HUMAN]] Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).<ref>PMID:10022127</ref> <ref>PMID:15820681</ref> <ref>PMID:16751102</ref> <ref>PMID:19135894</ref> 
(as it appears on PubMed at http://www.pubmed.gov), where 22196728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22196728}}


==About this Structure==
==About this Structure==
[[3u5p]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5P OCA].  
[[3u5p]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5P OCA].  
 
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]


==Reference==
==Reference==
<ref group="xtra">PMID:022196728</ref><references group="xtra"/>
<ref group="xtra">PMID:022196728</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
[[Category: Wang, Z.]]
[[Category: Wang, Z.]]
Retrieved from "https://proteopedia.org/3u5p"