3udy: Difference between revisions
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[[Image:3udy.jpg|left|200px]] | |||
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{{STRUCTURE_3udy| PDB=3udy | SCENE= }} | |||
===Crystal Structure of BACE with Compound 11=== | |||
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{{ABSTRACT_PUBMED_22468999}} | |||
==About this Structure== | |||
[[3udy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDY OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022468999</ref><ref group="xtra">PMID:018289105</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | |||
[[Category: Borzilleri, K.]] | |||
[[Category: Capetta, S.]] | |||
[[Category: Connell, T O.]] | |||
[[Category: Dorff, P.]] | |||
[[Category: Dutra, J.]] | |||
[[Category: Efremov, I V.]] | |||
[[Category: Mansour, M.]] | |||
[[Category: Oborski, C.]] | |||
[[Category: Pandit, J.]] | |||
[[Category: Sullivan, T J.O.]] | |||
[[Category: Vajdos, F F.]] | |||
[[Category: Wang, H.]] | |||
[[Category: Withka, J.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 07:48, 18 April 2012
Crystal Structure of BACE with Compound 11
Template:ABSTRACT PUBMED 22468999
About this Structure
3udy is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Efremov IV, Vajdos FF, Borzilleri K, Capetta S, Dorff PH, Dutra JK, Mansour M, Chen H, Goldstein SW, Noell S, Oborski CE, O'Connell TN, O'Sullivan TJ, Pandit J, Wang H, Wei B, Withka JM, McColl A. Discovery and Optimization of a Novel Spiro-pyrrolidine Inhibitors of beta-Secretase (BACE1) Through Fragment Based Drug Design. J Med Chem. 2012 Apr 2. PMID:22468999 doi:10.1021/jm201715d
- Tomasselli AG, Paddock DJ, Emmons TL, Mildner AM, Leone JW, Lull JM, Cialdella JI, Prince DB, Fischer HD, Heinrikson RL, Benson TE. High yield expression of human BACE constructs in Eschericia coli for refolding, purification, and high resolution diffracting crystal forms. Protein Pept Lett. 2008;15(2):131-43. doi: 10.2174/092986608783489553. PMID:18289105 doi:https://dx.doi.org/10.2174/092986608783489553
