Saposin

Saposin (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains and 2 SapA domains which are cleaved off. For more details see Molecular Playground/Saposin C.

3D Structures of Saposin

Saposin A

2dob – hSapA residues 60-140 – human

Saposin B

1n69 – hSapB + lipid

Saposin C

1m12, 1sn6 – hSapC – NMR
2gtg, 2qyp, 2z9a – hSapC residues 311-391

Saposin D

3bqp, 3bqq, 2r1q, 2rb3 - hSapD residues 405-484
2r0r - hSapD residues 407-484 (mutant)

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Michal Harel, Alexander Berchansky