3qlf: Difference between revisions

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[[Image:3qlf.jpg|left|200px]]
[[Image:3qlf.png|left|200px]]


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===Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5===
===Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5===


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{{ABSTRACT_PUBMED_17355866}}
{{ABSTRACT_PUBMED_17355866}}


==About this Structure==
==About this Structure==
[[3qlf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLF OCA].  
[[3qlf]] is a 2 chain structure of [[C-Src tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLF OCA].  
 
==See Also==
*[[C-Src tyrosine kinase|C-Src tyrosine kinase]]


==Reference==
==Reference==

Revision as of 19:21, 25 July 2012

File:3qlf.png

Template:STRUCTURE 3qlf

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5

Template:ABSTRACT PUBMED 17355866

About this Structure

3qlf is a 2 chain structure of C-Src tyrosine kinase with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure. 2007 Mar;15(3):299-311. PMID:17355866 doi:10.1016/j.str.2007.01.015
  2. Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20;15(10):1015-22. PMID:18940662 doi:10.1016/j.chembiol.2008.09.007

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