2lm5: Difference between revisions

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~~[[Image:2lm5.jpg|left|200px]]~~

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===Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit===

==Function==

[[http://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN]] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>

==About this Structure==

[[2lm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM5 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Huang, H.]]

[[Category: Vogel, H J.]]

[[Category: Metal binding protein]]

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-[[Image:2lm5.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2lm5", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2lm5|  PDB=2lm5  |  SCENE=  }}
 ===Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit===
+{{ABSTRACT_PUBMED_22283712}}
+==Function==
+[[http://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN]] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>
 ==About this Structure==
 [[2lm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM5 OCA].
+==Reference==
+<ref group="xtra">PMID:022283712</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Huang, H.]]
 [[Category: Vogel, H J.]]
 [[Category: Metal binding protein]]