TBX5: Difference between revisions
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TBX5 is a protein of which mutants can cause the Holt-Oram syndrome. It has been crystallised twice, one with and one without the corresponding DNA. It is different from the [[TBX3]] and [[Brachyury]] structures in the way that it dimerises, and that it has been bound to a half-site rather than a full palindromic site. The difference in dimerisations calls into question whether these proteins dimerise naturally or, as their <i>in vivo</i> predicted binding sites suggest, bind monomerically to the DNA. These proteins generally do not dimerise in conserved regions. | TBX5 is a protein of which mutants can cause the Holt-Oram syndrome. It has been crystallised twice, one with and one without the corresponding DNA. It is different from the [[TBX3]] and [[Brachyury]] structures in the way that it dimerises, and that it has been bound to a half-site rather than a full palindromic site. The difference in dimerisations calls into question whether these proteins dimerise naturally or, as their <i>in vivo</i> predicted binding sites suggest, bind monomerically to the DNA. These proteins generally do not dimerise in conserved regions. | ||
A bioinformatic search suggests that two nuclear localisation signals exist, one in the T-box domain and one in the transactivation domain. | A bioinformatic search suggests that two nuclear localisation signals exist, one in the T-box domain and one in the transactivation domain. See also [[Transcription and RNA Processing]]. | ||
=Crystal structure= | =Crystal structure= | ||
