2hek: Difference between revisions
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==Overview== | ==Overview== | ||
Using single-wavelength anomalous dispersion data obtained from a | Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Adams, P | [[Category: Adams, P D.]] | ||
[[Category: BSGC, Berkeley | [[Category: BSGC, Berkeley Structural Genomics Center.]] | ||
[[Category: Jancarik, J.]] | [[Category: Jancarik, J.]] | ||
[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
[[Category: Kim, S | [[Category: Kim, S H.]] | ||
[[Category: Oganesyan, V.]] | [[Category: Oganesyan, V.]] | ||
[[Category: BR]] | [[Category: BR]] | ||
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[[Category: unknown function]] | [[Category: unknown function]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:41:00 2008'' | ||
Revision as of 15:41, 21 February 2008
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Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.
Overview
Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.
About this Structure
2HEK is a Single protein structure of sequence from Aquifex aeolicus with PO4, ZN, CL, BR, GDP and GOL as ligands. Known structural/functional Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, BC1, BC2, BC3, BC4, BC5, BC6, BC7, BC8, BC9, CC1, CC2, CC3 and CC4. Full crystallographic information is available from OCA.
Reference
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Aquifex aeolicus
- Single protein
- Adams, P D.
- BSGC, Berkeley Structural Genomics Center.
- Jancarik, J.
- Kim, R.
- Kim, S H.
- Oganesyan, V.
- BR
- CL
- GDP
- GOL
- PO4
- ZN
- Berkeley structural genomics center
- Bsgc
- Predominantly alpha helical protein with gdp binding site and active site being far from each other
- Protein structure initiative
- Psi
- Structural genomics
- Unknown function
