3u0r: Difference between revisions

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~~[[Image:3u0r.jpg|left|200px]]~~

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===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===

==Function==

[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>

==About this Structure==

[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Cho, J W.]]

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-[[Image:3u0r.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3u0r", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3u0r|  PDB=3u0r  |  SCENE=  }}
 ===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===
+{{ABSTRACT_PUBMED_22334682}}
+==Function==
+[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
 ==About this Structure==
 [[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].
+==Reference==
+<ref group="xtra">PMID:022334682</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cho, J W.]]