Nucleoprotein: Difference between revisions
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[[Image:3pto.png|left|200px|thumb|Crystal Structure of Nucleoprotein [[3pto]]]] | [[Image:3pto.png|left|200px|thumb|Crystal Structure of Nucleoprotein [[3pto]]]] | ||
{{STRUCTURE_3pto| PDB=3pto | SIZE= | {{STRUCTURE_3pto| PDB=3pto | SIZE=400| SCENE=Nucleoprotein/Cv/1 |right|CAPTION=Nucleoprotein from vescicular stomatitis Indiana virus complex with uranyl ions [[3pto]] }} | ||
'''Nucleoproteins''' (NP) are associated with DNA or RNA. NPs which contain RNA are called ribonucleoproteins (RNPs). The NP RNA-recognition motif is named RRM. The small nuclear ribonucleoproteins (snRNPs) are RNA-protein complexes which form part of the spliceosome. The heterogenous nuclear ribonucleoproteins (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA. The images at the left and at the right correspond to one representative NP, ''i.e.'' the crystal structure of Nucleoprotein from Vesicular stomatitis Indiana virus ([[3pto]]). For homology model and multiple sequence alignment see [[User:Michael Strong/H1N1/NP]] and [[User:Michael Strong/H1N1/NP/MSA]]. | '''Nucleoproteins''' (NP) are associated with DNA or RNA. NPs which contain RNA are called ribonucleoproteins (RNPs). The NP RNA-recognition motif is named RRM. The small nuclear ribonucleoproteins (snRNPs) are RNA-protein complexes which form part of the spliceosome. The heterogenous nuclear ribonucleoproteins (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA. The images at the left and at the right correspond to one representative NP, ''i.e.'' the crystal structure of Nucleoprotein from Vesicular stomatitis Indiana virus ([[3pto]]). For homology model and multiple sequence alignment see [[User:Michael Strong/H1N1/NP]] and [[User:Michael Strong/H1N1/NP/MSA]]. | ||
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== 3D Structures of Nucleoprotein == | == 3D Structures of Nucleoprotein == | ||
''Updated | ''Updated June 2012'' | ||
===Nucleoprotein=== | ===Nucleoprotein=== | ||
[[3ouo]], [[3ov9]] – NP – Rift valley fever virus<br /> | [[3ouo]], [[3ov9]] – NP – Rift valley fever virus<br /> | ||
[[3q7b]], [[3q7c]] | [[3q7b]], [[3q7c]] – LvNP exonuclease domain – Lassa virus<br /> | ||
[[3mwp]], [[3mwt]], [[3r3l]] – LvNP<br /> | |||
[[3pto]] - VvNP – Vesicular stomatitis Indiana virus<br /> | [[3pto]] - VvNP – Vesicular stomatitis Indiana virus<br /> | ||
[[2qvj]] – VvNP (mutant)<br /> | [[2qvj]] – VvNP (mutant)<br /> | ||
[[2k48]] – NP N terminal – Andes virus - NMR<br /> | [[2k48]] – NP N terminal – Andes virus - NMR<br /> | ||
[[1ssk]] - ScvNP N terminal – SARS coronavirus – NMR<br /> | |||
[[2gib]] – ScvNP dimerization domain<br /> | |||
[[2jw8]] - ScvNP dimerization domain – NMR<br /> | |||
[[2ofz]], [[2og3]] - ScvNP RNA-binding domain<br /> | |||
[[3hd4]] – NP N terminal – Murine hepatitis virus<br /> | [[3hd4]] – NP N terminal – Murine hepatitis virus<br /> | ||
[[2wfs]] – IvNP – Cryo EM – Influenza virus<br /> | [[2wfs]] – IvNP – Cryo EM – Influenza virus<br /> | ||
[[2q06]], [[2iqh]] – IvNP<br /> | [[2q06]], [[2iqh]] – IvNP<br /> | ||
[[2i8b]] – | [[2i8b]] – EvNP C terminal – Ebola virus – NMR<br /> | ||
[[3v7o]] - EvNP C terminal<br /> | |||
[[1yvr]] – XlNP Ro – ''Xenopus laevis''<br /> | [[1yvr]] – XlNP Ro – ''Xenopus laevis''<br /> | ||
[[1wwf]] – MvNP P10 – Moloney murine leukemia virus – NMR<br /> | [[1wwf]] – MvNP P10 – Moloney murine leukemia virus – NMR<br /> | ||
[[2c86]] – BvNP N terminal – Avian infectious bronchitis virus<br /> | [[2c86]], [[2gec]] – BvNP N terminal – Avian infectious bronchitis virus<br /> | ||
[[2ca1]] – BvNP dimerization domain<br /> | [[2ca1]], [[2ge7]], [[2ge8]] – BvNP dimerization domain<br /> | ||
[[2btl]], [[2bxx]] – BvNP RRM (mutant)<br /> | [[2btl]], [[2bxx]] – BvNP RRM (mutant)<br /> | ||
[[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br /> | [[1n93]], [[1pp1]] – NP P40 – Borna disease virus<br /> | ||
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[[3mx2]], [[3mx5]] – LvNP + nucleotide<br /> | [[3mx2]], [[3mx5]] – LvNP + nucleotide<br /> | ||
[[3t5n]], [[3tsq]] – LvNP + RNA<br /> | |||
[[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br /> | [[3ptx]], [[3pu0]], [[3pu1]], [[3pu4]], [[2gic]] – VvNP + RNA<br /> | ||
[[2wyy]] – VvNP + poly U – Cryo EM<br /> | [[2wyy]] – VvNP + poly U – Cryo EM<br /> | ||
[[3hhw]] – VvNP + phosphoprotein<br /> | [[3hhw]], [[3pmk]] – VvNP + phosphoprotein<br /> | ||
[[3hhz]] - VvNP + phosphoprotein + RNA<br /> | [[3hhz]] - VvNP + phosphoprotein + RNA<br /> | ||
[[2wj8]] – NP + RNA – Human respiratory syncytial virus<br /> | [[2wj8]], [[2yhm]] – NP + RNA – Human respiratory syncytial virus<br /> | ||
[[2i91]], [[1yvp]] – XlNP Ro + RNA <br /> | [[2i91]], [[1yvp]] – XlNP Ro + RNA <br /> | ||
[[2gtt]] – NP + RNA – Rabies virus<br /> | [[2gtt]] – NP + RNA – Rabies virus<br /> | ||
[[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br /> | [[1wwg]], [[1wwd]], [[1wwe]], [[1u6p]] - MvNP P10 + RNA – NMR<br /> | ||
[[3ro5]] – IvNP + ligand | |||
===Ribonucleoprotein=== | ===Ribonucleoprotein=== | ||
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[[3s01]] – m-hnRNP L RRM3 domain – mouse<br /> | [[3s01]] – m-hnRNP L RRM3 domain – mouse<br /> | ||
[[3tyt]] - m-hnRNP L<br /> | |||
[[2e5i]] - m-hnRNP L RRM – NMR<br /> | [[2e5i]] - m-hnRNP L RRM – NMR<br /> | ||
[[2db1]] - m-hnRNP F RRM – NMR<br /> | [[2db1]] - m-hnRNP F RRM – NMR<br /> | ||
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[[2ad9]], [[2adb]], [[2adc]] - h-hnRNP I – NMR<br /> | [[2ad9]], [[2adb]], [[2adc]] - h-hnRNP I – NMR<br /> | ||
[[1zzk]] - h-hnRNP K KH domain<br /> | [[1zzk]] - h-hnRNP K KH domain<br /> | ||
[[3r27]] - h-hnRNP L RRM<br /> | [[3r27]], [[3t08]] - h-hnRNP L RRM<br /> | ||
[[2do0]], [[2dh9]], [[2dgv]] - h-hnRNP M RRM – NMR<br /> | [[2do0]], [[2dh9]], [[2dgv]] - h-hnRNP M RRM – NMR<br /> | ||
[[2dgu]] - h-hnRNP Q RRM – NMR<br /> | [[2dgu]] - h-hnRNP Q RRM – NMR<br /> | ||
